I've linked to comics I've liked in the past, and have been meaning to do the same with this one for a while. Starslip Crisis is the cleverest web comic I read. Set in the year 3441, the crew of the Starship Fuseli take art and culture to the furthest reaches of the Galaxy.
The Fuseli is a museum starship, and its curator Memnon Vanderbeam is fussy, arrogant and rude, but also loyal, brave and a damn good captain in a pinch. Cutter Edgewise is co-captain (much to Vanderbeam's disgust)
- an ex-pirate and drunk, but also a damn fine captain in a pinch. Together with Mr. Jinx (an alien with all sorts of get-out-of-jail-free bodily excretions) they boldly venture into pop-culture parody, art critique, and humour via some really dramatic moments.